Recent advancements in drug synthesis processes and targeted receptors have led to an increase in the number of novel drugs under development, characterized by poor aqueous solubility and other challenging properties. These unfavorable physical and chemical characteristics have created a demand for excipients and processes that enhance drug solubility and/or permeability, ultimately increasing potential bioavailability.
IFF’s Pharma Solutions versatile cellulose-based excipient – AFFINISOL™ HPMC HME – can help manufacturers overcome solubility challenges in a variety of dosage forms to deliver high-performance, stable and water-soluble pharmaceutical products. The revolutionary properties of AFFINISOL™ HPMC HME, which enable hot-melt extrusion (HME) across a wide range of processing conditions, are also responsible for enhancing the solubility of the polymer in a series of commonly used spray-drying (SD) solvents.
Application | Product recommendations | |
|---|---|---|
Hot-Melt Extrusion | AFFINISOL™ HPMC HME Grade | Recommended Ectrusion Temperature Range (no plasticizer) |
15 LV | 135 - 190°C | |
100 LV | 145 - 195°C | |
4M | 155 - 200°C | |
Hot Melt Extrusion with Extended Release | AFFINISOL™ HPMC HME 4M | |
Spray-Drying | AFFINISOL™ HPMC HME 15LV | |
*Examples only and not representative of a complete list of recommended products or benefits.
Learn more about how we can support your formulation.
Learn more about how we can support your formulation.
