A cell-compatible methyl cellulose for biotech applications

METHONOVA™ is the latest addition to our renowned NovaMatrix® range, a trusted portfolio of biopolymers tailored for use in the biotechnology industry. Our METHONOVA™ methyl cellulose builds on decades of polymer science expertise and meets the exacting standards of NovaMatrix®, undergoing elaborate quality testing for bioburden and elemental impurities.

METHONOVA™ has a low fiber content, easing sterile filtration to create a highly purified product suitable for use in cell culture. Cytotoxicity testing ensures METHONOVA™ is compatible with cells. Our cutting-edge solution is responsibly sourced, and adheres to stringent product specifications, making it a preferred choice for high-quality biotechnology and bioprocessing applications.

Chemistry

 

 

METHONOVA™ is a plant-based, water-soluble biopolymer derived from cellulose, the most abundant polymer in nature. METHONOVA™ methyl cellulose is a natural carbohydrate composed of repeating anhydroglucose units. During manufacture, cellulose fibers are treated with a caustic solution, followed by methyl chloride treatment, yielding the methyl ether of cellulose. The fibrous reaction product is purified and ground to a fine powder.

Product benefits

• Ease of sterile filtration
• Cell compatibility, verified via cytotoxicity test to mammalian cells
• Stringent quality standards
• Outstanding viscosity stability during long-term storage
• Water-solubility
• Reverse thermo-gelation properties
• Xeno-free formulation

Key applications

METHONOVA™ methyl cellulose is suitable for use in:

• Cell culture assays
• Stem cell protection
• Cryopreservation and cell media
• 3D bioprinting

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Regulatory

METHONOVA™ methyl cellulose is manufactured under excipient cGMP requirements. It is certified to meet the respective monographs: USP (United States Pharmacopeia), EP/PhEur (European Pharmacopeia) and JP (Japanese Pharmacopeia).