Finding a solution for poorly soluble drug compounds is the leading challenge faced by the pharmaceutical industry. AFFINISOL™ hydroxypropyl methylcellulose (HPMC) is a water-soluble cellulosic polymer from Pharma Solutions, designed to enhance the solubility of drugs and unlock their full therapeutic potential.
Our AFFINISOL™ HPMC HME polymers are uniquely tailored to address solubility by maintaining stable solid dispersions and inhibiting the recrystallization of APIs in formulation via hot melt extrusion (HME) or spray-drying (SD). Through these actions, AFFINISOL™ HPMC HME helps to simplify formulation requirements, improve physical stability and boost versatility in drug release profiles; improving the solubility and bioavailability for both immediate release and controlled release applications.
- Solubility enhancer
- Stabilizing polymer
- Versatile thermal processability
- Soluble in organic solvent
- Expands functionality of immediate release and controlled release drugs
- Solubility enhancement
- Hot melt extrusion and melt granulation
- Spray-drying
Product recommendations
*Examples only and not representative of a complete list of recommended products or benefits.
Applications | Recommended Grades | Benefits |
|---|---|---|
Hot Melt Extrusion | AFFINISOL™ HPMC HME 15LV, 100LV, 4M | Extrudable HPMC with processing versatility that requires no plasticizer and provides expanded IR and CR functionality |
Spray Dried Dispersions | AFFINISOL™ HPMC HME 15LV | Greater organic solvent solubility allows co-dissolusion of poorly soluable drug and stabilizing polymer |
We can help you along your product development process. Contact us to start your journey to success.
We can help you along your product development process. Contact us to start your journey to success.
