Innovations to solve the insoluble

Recent advancements in drug synthesis processes and targeted receptors have led to an increase in the number of novel drugs under development, characterized by poor aqueous solubility and other challenging properties. These unfavorable physical and chemical characteristics have created a demand for excipients and processes that enhance drug solubility and/or permeability, ultimately increasing potential bioavailability.

Powerful solubility solutions with AFFINISOL™ HPMC HME

IFF Pharma Solutions versatile cellulose-based excipient – AFFINISOL™ HPMC HME – can help manufacturers overcome solubility challenges in a variety of dosage forms to deliver high-performance, stable and water-soluble pharmaceutical products. The revolutionary properties of AFFINISOL™ HPMC HME, which enable hot-melt extrusion (HME) across a wide range of processing conditions, are also responsible for enhancing the solubility of the polymer in a series of commonly used spray-drying (SD) solvents.

Solubility enhancement
Application	Product recommendations
Hot-Melt Extrusion	AFFINISOL™ HPMC HME Grade	Recommended Ectrusion Temperature Range (no plasticizer)
	15 LV	135 - 190°C
	100 LV	145 - 195°C
	4M	155 - 200°C
Hot Melt Extrusion with Extended Release	AFFINISOL™ HPMC HME 4M
Spray-Drying	AFFINISOL™ HPMC HME 15LV

*Examples only and not representative of a complete list of recommended products or benefits.